Antioxidants Network - How the Antioxidant Network Modulates Gene Expression -

Oxidant Sensitive Signal Transduction and Gene Expression

Recently we have learned that many of the major pathways involved in signal transduction and gene expression can be regulated by oxidants and by redox-sensitive steps. Major systems known to be affected by oxidants and redox-sensitive steps appear above. Nuclear transcription factor NF-kB, is involved in inflammatory responses, AP-1 is important for cell growth and differentiation and p53 is a gene whose disruption is associated with more than half of all human cancers. The p53 protein guards a cell-cycle checkpoint, and inactivation of p53 allows uncontrolled cell division.

Those antioxidants which affect the steady state level of oxidants and which can modify the redox status of the cell will exert a regulatory effect on transcriptional activation and gene expression.

Information and statements regarding dietary supplements herein has not been evaluated by the Food and Drug Administration and is not intended to diagnose, treat, cure, or prevent any disease. Nor is it meant to substitute for the advice provided by your health care provider. The efficacy of antioxidant supplementation for children and during pregnancy is not established . If you have or suspect that you have a medical problem, please contact your physician.